Piccirillo, C.Pullar, R. C.Costa, E.Santos-Silva, A.Pintado, ManuelaCastro, Paula M. L.2016-04-212016-04-2120150928-4931http://hdl.handle.net/10400.14/19931Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/beta-tricalcium phosphate (HAp/beta-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.engHydroxyapatiteBioactivityHaemolysisSinteringjournal article10.1016/j.msec.2015.03.0201873-01918492545274525842140000353746400040