Rodrigues, DinaFreitas, Ana C.Queirós, RuiRocha-Santos, Teresa A. P.Saraiva, Jorge A.Gomes, Ana M. P.Duarte, Armando C.2017-10-122017-10-122017Rodrigues, D., Freitas, A. C., Queirós, R., Rocha-Santos, T. A.P., Saraiva, J. A., Gomes, A. M.P. and Duarte, A. C. (2017). Bioactive Polysaccharides Extracts from Sargassum muticum by High Hydrostatic Pressure. Journal of Food Processing and Preservation, 41(1), 1-120145-8892http://hdl.handle.net/10400.14/23048Sargassum muticum is an important source of bioactive polysaccharides; hence, high hydrostatic pressure (HHP) was used to improve their extraction efficiency. Response surface methodology and a Box-Behnken full factorial design were employed to assess and optimize the effects of extraction conditions on the yield, total sugars, total sulfated sugars and antioxidant activity of S. muticum extracts. The extraction yield ranged between 32 and 40.4% independently of the extraction conditions or seaweed solid/liquid ratio resulting in average increases of 3.6 to 4.8-fold for total sugars and sulfated sugars, as compared to conventional extraction. Extracts displayed improved antioxidant activities, yet maximum values were achieved under different optimum conditions of HHP processing, for example, 5–5.5 min, 300 MPa and 1 g of dry seaweed for yield. In conclusion, the optimal HHP technology conditions described in this paper enables to obtain enriched bioactive polysaccharide S. muticum extracts.engjournal article10.1111/jfpp.129771745-454984977485524000394816700076