Bernardes, Beatriz G.Sousa, ClaraSellitto, Maria RosariaIglesias-Mejuto, AnaGaudio, Pasquale delCosta, RaquelGarcía-González, Carlos A.Oliveira, Ana Leite2026-01-302026-01-302026-01-23Bernardes, B. G., Sousa, C., Sellitto, M. R., & Iglesias-Mejuto, A. et al. (2026). Design and characterization of biopolymer-based core–shell particles for sustained release of adenosine in tissue regeneration. 1-1. Poster session presented at 5ª Jornada de IBEROS+, Santiago de Compostela, Spain.6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2bhttp://hdl.handle.net/10400.14/56814The treatment of chronic wounds remains a formidable challenge in regenerative medicine, necessitating multifunctional biomaterials capable of modulating inflammation, promoting angiogenesis, and enabling sustained drug delivery [1]. This study presents a novel class of core–shell aerogel particles engineered from silk fibroin (SF), silk sericin (SS), and alginate (ALG), designed for the controlled release of adenosine (ADO)—a nucleoside with anti-inflammatory and pro-regenerative properties [2]. Using coaxial prilling and supercritical CO? drying, two architectures were fabricated: SF/ALG cores enveloped by ALG or ALG/SS shells.engconference poster not in proceedings10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b