Fonseca, M.Machado, D.Vedor, R.Andrade, J. C.Gomes, A. M.Barbosa, J. C.2024-07-082024-07-082024-07http://hdl.handle.net/10400.14/45698The World Health Organization estimates that the number of antibiotic resistance-related deaths could reach 10 million by 2050 [1]. Given the dynamics and high diversity of microorganisms that inhabit the gastrointestinal tract, this is the ideal place to discover new antimicrobial peptides (AMP) to replace traditional antibiotics [2]. Among the most extensively studied members are the commensal strains Akkermansia muciniphila DSM 22959 and Faecalibacterium duncaniae DSM 17677, which are reported to have a beneficial impact on intestinal health [3;4]. Antimicrobial peptides are small molecules that act as the first line of defense against microbial invaders, playing a vital role in the innate immune system [5]. One approach to identify new strategies to combat antimicrobial resistance is to evaluate the ability of these bacteria to produce AMP.engconference object