Fernandes, João C.Spindola, HumbertoSousa, Vanessa deSantos-Silva, AlicePintado, Manuela E.Malcata, Francisco XavierCarvalho, João E.2023-03-222023-03-222010-061660-3397http://hdl.handle.net/10400.14/40675All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.engAnimal modelAnti-inflammatoryChitooligosaccharidesjournal article10.3390/md806176377954239729PMC290182320631868000280347000004