Santos, Marcus Vinicius Beserra dosRocha, Lorenna Bastos NogueiraVieira, Ewerton GomesOliveira, Ana LeiteLobo, Anderson OliveiraCarvalho, Maria Acelina Martins deOsajima, Josy AnteveliSilva-Filho, Edson Cavalcanti2019-08-092019-08-092019Vinicius Beserra dos Santos, M., Bastos Nogueira Rocha, L., Gomes Vieira, E., Leite Oliveira, A., Oliveira Lobo, A., de Carvalho, M. A. M., … Cavalcanti Silva-Filho, E. (2019). Development of Composite Scaffolds Based on Cerium Doped-Hydroxyapatite and Natural Gums—Biological and Mechanical Properties. Materials, 12(15), 2389. https://doi.org/10.3390/ma12152389http://hdl.handle.net/10400.14/28135Hydroxyapatite (HAp) is a ceramic material composing the inorganic portion of bones. Ionic substitutions enhance characteristics of HAp, for example, calcium ions (Ca2+) by cerium ions (Ce3+). The use of HAp is potentialized through biopolymers, cashew gum (CG), and gellan gum (GG), since CG/GG is structuring agents in the modeling of structured biocomposites, scaffolds. Ce-HApCG biocomposite was synthesized using a chemical precipitation method. The obtained material was frozen (–20 °C for 24 h), and then vacuum dried for 24 h. The Ce-HApCG was characterized by X-Ray diffractograms (XRD), X-ray photoemission spectra (XPS), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and energy dispersive spectroscopy (EDS). XRD and FTIR showed that Ce-HApCG was successfully synthesized. XRD showed characteristic peaks at 2θ = 25.87 and 32.05, corresponding to the crystalline planes (0 0 2) and (2 1 1), respectively, while phosphate bands were present at 1050 cm−1 and 1098 cm−1, indicating the success of composite synthesis. FESEM showed pores and incorporated nanostructured granules of Ce-HApCG. The mechanical test identified that Ce-HApCG has a compressive strength similar to the cancellous bone’s strength and some allografts used in surgical procedures. In vitro tests (MTT assay and hemolysis) showed that scaffold was non-toxic and exhibited low hemolytic activity. Thus, the Ce-HApCG has potential for application in bone tissue engineering.engCalcium phosphateDopingScaffoldjournal article10.3390/ma121523891996-194485070408849PMC669579431357470000482576900050