Correia, Rion BrattigRozum, Jordan C.Cross, LeonardFelag, JackGallant, MichaelGuo, ZiqiHerr II, Bruce W.Min, AehongSanchez-Valle, JonRocha, Deborah StungisValencia, AlfonsoWang, XuanBörner, KatyMiller, WendyRocha, Luis M.2025-02-252025-02-252025-01-311067-5027http://hdl.handle.net/10400.14/48293Objectives: Report the development of the patient-centered myAURA application and suite of methods designed to aid epilepsy patients, caregivers, and clinicians in making decisions about self-management and care. Materials and Methods: myAURA rests on an unprecedented collection of epilepsy-relevant heterogeneous data resources, such as biomedical databases, social media, and electronic health records (EHRs). We use a patient-centered biomedical dictionary to link the collected data in a multilayer knowledge graph (KG) computed with a generalizable, open-source methodology. Results: Our approach is based on a novel network sparsification method that uses the metric backbone of weighted graphs to discover important edges for inference, recommendation, and visualization. We demonstrate by studying drug-drug interaction from EHRs, extracting epilepsy-focused digital cohorts from social media, and generating a multilayer KG visualization. We also present our patient-centered design and pilot-testing of myAURA, including its user interface. Discussion: The ability to search and explore myAURA’s heterogeneous data sources in a single, sparsified, multilayer KG is highly useful for a range of epilepsy studies and stakeholder support. Conclusion: Our stakeholder-driven, scalable approach to integrating traditional and nontraditional data sources enables both clinical discovery and data-powered patient self-management in epilepsy and can be generalized to other chronic conditions.engData visualizationEpilepsySelf-managementSemantic webSocial mediaSystems analysisjournal article10.1093/jamia/ocaf01239890454001410117600001