Percorrer por autor "Santos, Susana"
A mostrar 1 - 3 de 3
Resultados por página
Opções de ordenação
- Prostate cancer progression: a scoping review, pharmacoeconomic assessment, and evaluation of quality of lifePublication . Dinis de Sousa, Rute; Zagalo, Daniela Mariana; Gouveia, Miguel; Gomes, Luís; Santos Dias, José; Mansinho, André; Santos, Susana; Mariano, José; Canhão, Helena; Rodrigues, AnaAIMS/BACKGROUND: Prostate cancer is the most common malignancy in men and a leading cause of cancer-related death. Progression from non-metastatic castration-resistant prostate cancer (nmCRPC) to metastatic CRPC (mCRPC) significantly worsens health-related quality of life (HRQoL), increases mortality, and raises healthcare costs. This study assessed the impact of avoiding or delaying progression to mCRPC on HRQoL, mortality, and economic outcomes, incorporating patients' lived experiences and unmet needs. METHODS: Three complementary studies were conducted. Study 1 was a scoping review of HRQoL and functional outcomes across disease stages, analyzing 56 studies (27 RCTs, 29 observational). Study 2 used a pharmacoeconomic survival-partition model of apalutamide, calibrated for the Portuguese healthcare system, to estimate utility gains, mortality impacts, and healthcare costs associated with delaying progression (excluding drug costs). Study 3 comprised two virtual focus groups (n?=?5) exploring patient experiences, including symptom burden, psychological impact, daily life disruption, coping strategies, and care-related unmet needs. RESULTS: High-risk nmCRPC patients had higher HRQoL and better function than mCRPC patients. Symptomatic mCRPC had the lowest HRQoL (EQ-5D 0.63-0.90 vs 0.85-0.86; FACT-P 93-123 vs 109-121). Delaying progression yielded an estimated utility gain of 0.192, reduced annual mortality (0.1% vs 19.1%), and 4.4-fold lower healthcare costs. Focus groups confirmed greater physical symptoms, emotional distress, and social disruption in mCRPC, while nmCRPC experiences centered on monitoring and uncertainty. Patients identified gaps in supportive care, including psychosocial, sexual, and functional needs. CONCLUSIONS: Delaying progression from nmCRPC to mCRPC confers substantial HRQoL, survival, and economic benefits. Patient perspectives highlight gaps in supportive care and the value of early targeted interventions. LIMITATIONS: Small qualitative sample, reliance on baseline HRQoL without longitudinal adjustment, heterogeneity across studies, and exclusion of nmCRPC treatment costs may limit generalizability and precision.
- The impact of social media on women's paths to cosmetic enhancementPublication . Santos, Susana; Chagas, Bernardo; Tavares, PatríciaThis study examines the role of social media and social media influencers in shaping self-perceptions and decisions related to cosmetic procedures. It aims to clarify how social media influences the customer’s path towards cosmetic enhancements. Interviews with women who had procedures reveal that comparisons to online images negatively affect self-image. Influencers notably affect non-invasive procedure decisions, while invasive ones are influenced by lasting dissatisfaction and familial opinions. However, low self-esteem and comparison with self-edited images play significant roles. Findings contribute to academia, practitioners, and policymakers,shedding light on the multifaceted influences on cosmetic procedure choices.
- We need challenges!: the case on four project-based learning initiatives at portuguese higher education institutionsPublication . Araújo, Patrícia; Santos, Susana; Oliveira, Eva Dias deProject-Based Learning (PBL) is a methodology with roots in the work of educational philosopher John Dewey (1 95 9) and it is now, more than ever, essential in educational practices. Higher Education (HE) needs to refine andragogic practices and challenges related to the new generation of students (Millennials), who value learning by doing, technology and a global and eclectic approach, and PBL is as an optimal solution. Although this is widely spread among HE teachers, they still have limitations when implementing PBL and further training is needed in order to implement successful practices (Bilgin, Karakuyu, & Ay, 2015). The aim of this Multiple Case Study is to present and analyze four PBL practices in HE in Portugal: 'Ipam Leadership Challenge', 'One Pitch, one Cause, 'Arcadia Challenge' and 'ESB Delivering science into the community'. The outline of the Buck Institute for Education (BIE) will be used as a framework of analysis, which defines PBL as a teaching method in which students gain knowledge and skills by working for an extended period of time to investigate and respond to an authentic, engaging and complex question, problem, or challenge. This approach uses the 8 Essential Elements of PBL(Mergendoller & Larmer, 2015): (i) Key Knowledge, Understanding, and Success Skills: (ii) Challenging Problem or Question; (iii) Sustained Inquiry; (iv) Authenticity; (v) Student Voice & Choice; (vi) Reflection; (vii) Critique & Revision and (viii) Public Product. We finish with a brief discussion and reflections on the future of PBL at HE institutions.