Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/9976
Título: Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model
Autor: Fernandes, João C.
Sereno, José
Garrido, Patricia
Parada, Belmiro
Cunha, Maria F. X.
Reis, Flávio
Pintado, M. E.
Santos-Silva, Alice
Palavras-chave: Chitosans
Bladder Cancer
Chemoprevention
Chitooligosaccharides
Data: 2012
Editora: MDPI - Multidisciplinary Digital Publishing Institute
Citação: FERNANDES, João C... [et al.] - Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model. Marine Drugs. ISSN 1660-3397. Vol. 10, n.º 12 (2012), p. 2661-2675
Resumo: Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile.
Peer review: yes
URI: http://hdl.handle.net/10400.14/9976
Versão do Editor: http://www.mdpi.com/1660-3397/10/12/2661
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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