Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/9967
Título: Evaluation and insights into chitosan antimicrobial activity against anaerobic oral pathogens
Autor: Costa, E. M.
Silva, S.
Pina, C. M. G.
Tavaria, Freni
Pintado, M. E.
Palavras-chave: Anaerobic pathogens
Antimicrobial
Chitosan
Action mechanism
Data: 2012
Editora: Elsevier
Citação: COSTA, E. M... [et al.] - Evaluation and insights into chitosan antimicrobial activity against anaerobic oral pathogens. Anaerobe. ISSN 1075-9964. Vol. 18, n.º 3 (2012), p. 305-309
Resumo: The objective of this study was to assess the antimicrobial capability of non-chemically altered chitosan as an alternative to traditional antimicrobials used in the treatment of oral infections. The action mechanism of chitosan was also ascertained. High and low molecular weight chitosan showed antimicrobial activity at low concentrations for all tested bacteria with the MICs varying between 1 and 7 mg/ ml with a drop of efficacy relatively to the action of LMW chitosan. In addition chitosan showed also to be an effective bactericidal presenting bactericidal effect within 8 h at the latest. Additionally the evaluation of chitosan’s action mechanism showed that both MWs acted upon the bacterial cell wall and were not capable of interacting with the intracellular substances, as showed by the inefficacy obtained in the flocculation assay
Peer review: yes
URI: http://hdl.handle.net/10400.14/9967
Versão do Editor: doi:10.1016/j.anaerobe.2012.04.009
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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