Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/7965
Título: Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus
Autor: Tavares, T.G.
Monteiro, K.M.
Possenti, A.
Pintado, M.E.
Carvalho, J.E.
Malcata, F.X.
Data: 2011
Editora: Elsevier
Citação: TAVARES, T.G... [et al.] - Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus. International Dairy Journal. ISSN 0958-6946. Vol. 21, n.º 12 (2011), p.934–939
Resumo: Peptide concentrates generated by hydrolysis of whey with aqueous extracts of flowers of Cynara cardunculus were studied for possible protection of the stomach mucosa against ulcerative lesions caused by oral administration of absolute ethanol. Both the whole peptide fraction obtained via hydrolysis of whey protein concentrate (peptide concentrate, PepC) and its fraction below 3 kDa (PepCF) were able to reduce gastric injuries to significant levels (p < 0.05). Single-dose experiments, using 100 mg kg−1 body weight (bw) of either PepCF or PepC, led to 68.5% and 37.4% protection, respectively – which compare well with 93.4% protection by 200 mg kg−1 bw carbenoxolone (a positive control). No dose-response correlation could be demonstrated. Gastric cytoprotection by PepCF appears to depend on sulphydryl-containing moieties, whereas PepC likely protects the gastric mucosa via the prostaglandin cycle and production of nitric oxide.
Peer review: yes
URI: http://hdl.handle.net/10400.14/7965
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0958694611001804
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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