Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/6701
Título: Economic criteria in the design of cascades of CSTR’s for the performance of Enzyme -c at a1 yzed reactions
Autor: Malcata, F. Xavier
Palavras-chave: Capital investment
Exponential factor rule
Michaelis-Menten reactions
Optimization
Data: 1997
Editora: Chemical Institute of Canada
Citação: MALCATA, F. Xavier - Economic Criteria in the Design of Cascades of CSTR’s for the Performance of Enzyme -c at a1 yzed Reactions. The Canadian Journal of Chemical Engineering. ISSN 1939-019X. Vol. 75, n.º 5 (1997), p. 984-989
Resumo: The mass balances on substrate in each unit of a series of CSTRs performing an enzyme-catalyzed reaction described by Michaelis-Menten kinetics (with parameter K,,,)a re written and the necessary and sufficient condition that must be satisfied by the intermediate concentrations in order to obtain a minimum overall capital investment is found on the assumption that the cost of each reactor unit scales up on its capacity according to a fractional factor exponential rule (with parameter n). The asymptotic situations of pseudo-zero order and pseudo-first order behavior are explored. The ratio between consecutive concentrations leading to a minimum overall capital investment decreases as K,,, decreases at a rate that is slower for higher n, and tends to unity as the pseudo-first order situation is approached. If fractional values of n are considered, local minima of the capital investment associated with the overall reactor cascade exist only in certain ranges of substrate conversion; below the lower limits of such ranges, the number of reactor units should actually be decreased. A graphical procedure aimed at obtaining the intermediate optimal concentrations is presented.
Peer review: yes
URI: http://hdl.handle.net/10400.14/6701
Versão do Editor: The definitive version is available at www3.interscience.wiley.com
Aparece nas colecções:ESB - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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