Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/6538
Título: Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method
Autor: Silva, J. P. S.
Ferreira, J. P. M.
Palavras-chave: Microencapsulation
Emulsion-solvent evaporation
Drug properties
Oral drug delivery
Data: 1999
Editora: Informa Healthcare
Citação: SILVA, J. P. S. ; FERREIRA, J. P. M. - Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method. Journal of Microencapsulation. ISSN 0265-2048. Vol. 16, n.º 1 (1999), p.95-103
Resumo: Drugs with different water-solubility and molecular weights were microencapsulated in cellulose acetate phthalate, using an emulsion-solvent evaporation technique with a continuous oil-phase. The mean size of the particles was approximately 600mum, and they were non-porous. The capacity of the microspheres to retain the drugs was evaluated by in vitro release studies in acidic medium. For low molecular weight compounds the release rates increased with solubility: for thiamin hydrochloride and phenacetin, a highly and a poorly soluble compound respectively, the percentages released at 60 min were 90 and 10%. Drugs with molecular weights above approximately 700 Da were retained in the microspheres. The above dependence on solubility was corroborated by release studies in ethanol, and by modelling the release of phenacetin in acidic media. Microspheres with a different polymer matrix, Eudragit RS PO, were also prepared by a similar technique, and these particles prolonged the release of thiamin for over 6h, under simulated GI conditions.
Peer review: yes
URI: http://hdl.handle.net/10400.14/6538
Versão do Editor: http://informahealthcare.com/doi/abs/10.1080/026520499289347?journalCode=mnc
Aparece nas colecções:ESB - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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