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Resumo(s)
The pathophysiological modifications underlying chronic which will determine the moment to start therapy. As there is yet
limited information about animal models of moderate chronic renal failure, we intended to perform a complete characterization
60 of the hematological and cardio-renal alterations induced by partial nephrectomy. Blood samples from control and chronic renal
failure rats were collected at 0, 3, 9, and 15 weeks in order to evaluate renal function, hematological parameters, iron metabolism, blood lipids, peripheral sympathetic nervous system, and
65 inflammatory and redoz status markers. BP, tissues trophy indexes, and kidney histomorphology were also assessed. Our
data are consistent with a sustained moderate degree of chronic renal failure with a quickly compensated modest anaemia,
though presenting iron metabolism disturbances. Despite the reasonable
degree of functionality of the remnant kidney, as sug- 70 gested by the anaemia correction and by the kidney hypertrophy
and moderate lesions, several important cardiovascular modifications
were developed. Our model presented hypertension, dyslipidemia,
erythropoietic disturbances, sympathetic activation, and oxidative stress. This model might be a good tool to study the
cellular/molecular mechanisms underlying moderate stages of chronic renal failure and to evaluate the therapeutic efficacy for
prevention and treatment/correction of cardio-renal anaemia syndromes and complications in early stages.
Descrição
Palavras-chave
Moderate renal failure Cardio-renal characterization Sympathetic activity Inflammation Oxidative stress
Contexto Educativo
Citação
GARRIDO; P.; REIS, F.; COSTA, Elísio - Characterization of a rat model of moderate chronic renal failure: focus on hematological, biochemical, and cardio-renal profiles. Renal Failure. ISSN 0886-022X. Vol. 31 (2009), p. 1-10
Editora
Informa Healthcare USA