Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/4376
Título: Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients
Autor: Costa, Elísio
Rocha, Susana
Rocha-Pereira, Petronila
Nascimento, Henrique
Castro, Elisabeth
Miranda, Vasco
Faria, Maria do Sameiro
Loureiro, Alfredo
Belo, Luís
Santos-Silva, Alice
Palavras-chave: rhEPO therapy, resistance
Neutrophil activation
Elastase
Lactoferrin
Data: 2008
Editora: Bakris G. (Chicago, Ill.)
Citação: COSTA, Elísio - Neutrophil activation and resistance to recombinant human erythropoietin therapy in Hemodialysis Patients.American Journal of Nephrology. ISSN 0250-8095. Vol.28 (2008) p. 935-940
Resumo: The aim of this work was to evaluate the neutrophil activation state in chronic kidney disease (CKD) patients under hemodialysis, and its linkage with resistance to recombinant human erythropoietin (rhEPO) therapy. Methods: We studied 63 CKD patients under hemodialysis and rhEPO treatment (32 responders and 31 non-responders to rhEPO therapy). In 20 of the CKD patients (10 responders and 10 non-responders to rhEPO therapy), blood samples were also collected immediately after dialysis. Twenty-six healthy volunteers were included in a control group. Hemoglobin levels, total and differential leukocyte counts, and circulating levels of C-reactive protein (CRP), elastase and lactoferrin were measured in all patients and controls. Results: Compared with controls, CKD patients presented with significantly higher CRP, neutrophil and elastase levels. When we compared the 2 groups of patients, we found that non-responders presented statistically significantly higher elastase plasma levels. A positive significant correlation was found between elastase levels and weekly rhEPO dose and CRP serum levels. After the hemodialysis procedure, a statistically significant rise in elastase, lactoferrin and, elastase/neutrophil and lactoferrin/neutrophil ratios were found. Conclusions: Our data show that CKD patients under hemodialysis present higher elastase levels (particularly in non-responding patients), which could be related to the rise in neutrophils, and to be part of the enhanced inflammatory process found in these patients
Peer review: yes
URI: http://hdl.handle.net/10400.14/4376
Versão do Editor: http://content.karger.com/ProdukteDB/produkte.asp?Doi=142147
Aparece nas colecções:ICS(P) - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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