Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/4375
Título: Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping
Outros títulos: Efeitos hemorreológicos e cardiovasculares da eritropoietina num modelo de rato em exercício físico sob a acção de drogas
Autor: Piloto, N.
Teixeira, HM
Garrido, P.
Teixeira-Lemos, E.
Teixeira, M.
Parada, B.
Sereno, J.
Pinto, R .
Alves, R.
Santos, P.
Romão, AM
Nunes, S.
Neto, P.
Carvalho, L.
Couceiro, P.
Xavier, F.
Rocha-Pereira, P.
Costa, Elísio
Belo, L.
Santos-Silva, A.
Teixeira, F.
Reis, F.
Palavras-chave: rhEPO
Doping
Chronic aerobic exercise
Hemorheological and cardiovascular (effects)
Data: 2010
Editora: Sociedade Portuguesa de Hemorreologia e Microcirculação.
Citação: PILOTO, N... [et al.] - Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping. Boletim Sociedade da Portuguesa de Hemorreologia e Microcirculação. ISSN 0872-4938.Vol. 25, n.º 1 (2010), p. 11 - 22.
Resumo: Recombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians.
Peer review: yes
URI: http://hdl.handle.net/10400.14/4375
Versão do Editor: http://www.hemorreologia.com/index.php?option=com_docman&task=cat_view&gid=36&Itemid=72
Aparece nas colecções:ICS(P) - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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