Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/4374
Título: Recombinant human erythropoietin therapy has beneffical cardio-renal effects on moderate stages of chronic renal failure in the rat
Autor: Garrido, P.
Reis, F.
Costa, Elísio
Parada, B.
Piloto, N.
Sereno, J.
Teixeira, A.
Pinto, R.
Figueiredo, A.
Alves, R.
Rocha-Pereira, P.
Belo, L.
Santos-Silva, A.
Teixeira, F.
Palavras-chave: Moderate chronic renal failure
rhEPO therapy
Cardio-renal effects
Data: 2009
Editora: Medimond S.r.l. - Monduzzi Editore International Proceedings Division
Citação: CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS, 9th. Edinburgh, Scotland, United Kingdom, 12-15 July, 2009. In Proceedings of the European Association for Clinical Pharmacology and Therapeutics, p. 177 - 180
Resumo: This study aimed to assess the cardio-renal effects of rhEPO therapy on an animal model of moderate chronic renal failure (CRF). Four groups (n =7) of male rat were evaluated during a 12-week follow up period: control; rhEPO: 50 IU/Kg/wk; CRF: two-stage 3/, nephrectomy; CRF+ rhEPO (start after the 3'd wk of surgery). Renal function, haematology and serum inflammation and redox status were assessed. rhEPO treatment was able to partially attenuate renal function markers, totally correct anaemia, also showing a proliferative and antioxidant action, due to increased serum TGF-13I and decreased 3-NT. In conclusion, rhEPO therapy might be recommended in moderate CRF stages in order to efficiently correct not only the underlying anaemia but also the deleterious cardio-renal effects, due to a proliferative and antioxidant renoprotective action.
Peer review: yes
URI: http://hdl.handle.net/10400.14/4374
Aparece nas colecções:ICS(P) - Artigos em actas / Papers in proceedings

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