Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/3732
Título: Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping
Autor: Piloto, Nuno
Teixeira, Helena M.
Teixeira-Lemos, Edite
Parada, Belmiro
Garrido, Patrícia
Sereno, José
Pinto, Rui
Carvalho, Lina
Costa, Elísio
Belo, Luís
Santos-Silva, Alice
Teixeira, Frederico
Reis, Flávio
Palavras-chave: rhEPO
Doping
Chronic aerobic exercise
Cardiovascular and mortality risk
Data: 2009
Editora: Humana Press (Springer Imprint)
Citação: PILOTO, Nuno...[et al.] - Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping. Cardiovascular Toxicology. ISSN 1559-0259. Vol. 9, n.º 4 (2009), p. 201-10
Resumo: Athletes who abuse recombinant human erythropoietin (rhEPO) consider only the benefit to performance and usually ignore the potential short and long-term liabilities. Elevated haematocrit and dehydratation associated with intense exercise may reveal undetected cardiovascular risk, but the mechanisms underlying it remain to be fully explained. This study aimed to evaluate the cardiovascular effects of rhEPO in rats under chronic aerobic exercise. A ten week protocol was performed in four male Wistar rat groups: control—sedentary; rhEPO—50 IU kg-1, 3 times/wk; exercised (EX)—swimming for 1 h, 3 times/wk; EX + rhEPO. One rat of the EX + rhEPO group suffered a sudden death episode during the week 8. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertrophy, sympathetic and serotonergic overactivation. The suddenly died rat’s tissues presented brain with vascular congestion; left ventricular hypertrophy, together with a ‘‘cardiac-liver’’, suggesting the hypothesis of heart failure as cause of sudden death. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected RBC count increment, suggesting hyperviscosity, but also other serious deleterious cardiovascular and thromboembolic modifications, including mortality risk, which might be known and assumed by all sports authorities, including athletes and their physicians.
Peer review: yes
URI: http://hdl.handle.net/10400.14/3732
Versão do Editor: The original publication is available at: http://www.springerlink.com/content/5v2k60725617x316/
Aparece nas colecções:ICS(P) - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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