Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/3025
Título: Resistance to recombinant human erythropoietin therapy in haemodialysis patients: Focus on inflammatory cytokines, leukocyte activation, iron status and erythrocyte damage
Autor: Costa, Elísio
Belo, Luís
Quintanilha, Alexandre
Santos-Silva, Alice
Palavras-chave: Haemodialysis
Resitance to rhEPO therapy
Erythropoietin
Inflammation
Leukocyte activation
Iron status
Erythrocyte damage
Data: 2009
Editora: OmniScientia
Citação: COSTA, Elísio; BELO, Luís - Resistance to recombinant human erythropoietin therapy in haemodialysis patients: Focus on inflammatory cytokines, leukocyte activation, iron status and erythrocyte damage. Journal of Nephrology and Renal Transplantation. ISSN 1918-025X. Vol. 2, n.º 3 (2009), p. 66–83
Resumo: Anaemia is a common complication in haemodialysis patients. This condition is associated to a decreased bone marrow production of erythrocytes, mainly due to the inability of the failing kidneys to secrete erythropoietin (EPO). The introduction of recombinant human EPO (rhEPO) therapy led to a significant reduction in anaemia and improved patients’ quality of life. However, there is a marked variability in the sensitivity to rhEPO, with up to 10-fold variability in dose requirements to achieve correction of anaemia. Approximately 5-10% of the patients show a marked resistance to rhEPO therapy. rhEPO resistance is associated to an increased morbidity and mortality of haemodialysis patients. In this paper a revision of the mechanisms underlying resistance to rhEPO therapy will be performed, with particular emphasis on inflammatory cytokines, leukocyte activation, iron status, and erythrocyte damage.
URI: http://hdl.handle.net/10400.14/3025
Versão do Editor: http://www.jnrt.info/ojs/index.php?journal=jnrt&page=issue&op=view&path[]=2%283%29
Aparece nas colecções:ICS(P) - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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