Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/17547
Título: Chitosan mouthwash: Toxicity and in vivo validation
Autor: Costa, E. M.
Silva, S.
Costa, M. R.
Pereira, M.
Camposa, D. A.
Odila, J.
Madureira, A. R.
Cardelle-Cobasa, A.
Tavaria, F. K.
Rodrigues, A. S.
Pintado, M. E.
Palavras-chave: Chitosan
Mouthwash
In Vivo
Ames
MTT
Antimicrobial
Data: 2014
Citação: COSTA, E. M. ...[et al.] - Chitosan mouthwash: Toxicity and in vivo validation. Carbohydrate Polymers. ISSN 0144-8617. Vol. 111 (2014), p. 385–392
Resumo: A previous study showed that a chitosan mouthwash would be a valid alternative to current mouthwashesas it demonstrated, in vitro, significantly higher antibiofilm activity than two commercial mouthwashes.As such, the aim of this work was to verify the safety of the developed product and to validate, in vivo, thebiological activity ascertained in vitro. Chitosan mouthwash safety was evaluated through Ames, MTT andV79 chromosomal aberration assay while antimicrobial activity was evaluated through in vivo assays. Theresults showed that the chitosan mouthwash was safe, presenting lower cytotoxicity than a commercialmouthwash, and that it effectively reduced viable counts of Streptococcus spp. and Enterococcus spp. by ca.5.5 log of CFU. Furthermore, in direct comparison with a commercial mouthwash the chitosan mouthwashpossessed significantly higher antimicrobial activity. The conjunction of these results proves that thechitosan mouthwash is a safe, effective, natural alternative to the existent chemical mouthwashes.
Peer review: yes
URI: http://hdl.handle.net/10400.14/17547
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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