Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/17535
Título: 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: Influence of endocannabinoid signalling in placental development
Autor: Costa, M. A.
Keating c, E.
Fonseca, B. M.
Teixeira, N. A.
Correia-da-Silva, G.
Palavras-chave: 2-arachinoylglycerol
Endocannabinoid signalling
Human cytotrophoblasts
Syncytialization
Placenta
Data: 2015
Citação: COSTA, M. A… [et al.] - 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: Influence of endocannabinoid signalling in placental development. Molecular and Cellular Endocrinology. ISSN 0303-7207. Vol. 399 (2015), p. 386-94
Resumo: A balanced cytotrophoblast cell turnover is crucial for placental development and anomalies in this process associated with gestational diseases. The endocannabinoid system (ECS) has emerged as a new player in several biological processes. However, its influence during placental development is still unknown. We report here the expression of the endocannabinoid 2-arachidonoylglycerol (2-AG) main metabolic enzymes in human cytotrophoblasts and syncytiotrophoblast. We also showed that 2-AG induced a decrease in placental alkaline phosphatase activity, human chorionic gonadotropin secretion and Leptin mRNA levels. Moreover, 2-AG reduced glial cell missing 1 and syncytin-2 transcription and the number of nuclei in syncytium. These effects were mediated by cannabinoid receptors and may result from 2-AG inhibition of the cAMP/PKA signalling pathway. Our data suggest that 2-AG may interfere with the biochemical and morphological differentiation of human cytotrophoblasts, through a CB receptor-dependent mechanism, shedding light on a role for the ECS in placental development.
Peer review: yes
URI: http://hdl.handle.net/10400.14/17535
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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