Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/17456
Título: Maternal undernutrition and fetal developmental programming of obesity: the glucocorticoid connection
Autor: Correia-Branco, Ana
Keating, Elisa
Martel, Fátima
Palavras-chave: Metabolic syndrome
Maternal undernutrition
Glucocorticoids
Fetal developmental programming
Data: 2015
Citação: CORREIA-BRANCO, Ana ; KEATING, Elisa ; MARTEL, Fátima - Maternal undernutrition and fetal developmental programming of obesity: the glucocorticoid connection. Reproductive Sciences. ISSN 1933-7205. Vol. 22, n.º 2 (2015), p. 138-145
Resumo: An adequatematernal nutrition during pregnancy is crucial for the health outcome of offspring in adulthood. Maternal undernutrition during critical periods of fetal development can program the fetus for metabolic syndrome (MetS) later in life, especially when postnatally challenged with a hypernutritive diet. Adipogenesis, which begins in utero and accelerates in neonatal life, is a major candidate for developmental programming. During fetal development, the hypothalamic–pituitary–adrenal (HPA) axis is extremely susceptible to programming, and the HPA tone is increased throughout life in undernourished conditions. As a consequence, an alteration in the expression and function of glucocorticoid (GC) receptors and of the major GC regulatory enzymes (11b-hydroxysteroid dehydrogenase 1 and -2) occurs. In this review, we will give insights into the role of maternoplacental adverse interactions under the specific context of maternal undernutrition, for later-in-lifeMetS development, with a special emphasis on the role of GCs.
Peer review: yes
URI: http://hdl.handle.net/10400.14/17456
Aparece nas colecções:CBQF - Recensão / Review

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