Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/14313
Título: Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies
Autor: Alves, M. J.
Ferreira, I.C.F.R.
Froufe, H.J.C.
Abreu, R.M.V.
Martins, A.
Pintado, M. E.
Palavras-chave: Antimicrobial activity
Clinical isolates
Docking
SAR
Wild mushrooms
Data: 2013
Editora: Wiley
Citação: ALVES, M.J. …[et al.] - Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies. Journal of Applied Microbiology. ISSN 1364-5072. Vol. 115, n.º 2 (2013), p. 346—357
Resumo: Aim and Methods: Although the antimicrobial activity of extracts from several mushroom species has been reported, studies with the individual compounds present in that extracts are scarce. Herein, the antimicrobial activity of different phenolic compounds identified and quantified in mushroom species from all over the world was evaluated. Furthermore, a structure–activity relationship (SAR) analysis and molecular docking studies were performed, in order to provide insights into the mechanism of action of potential antimicrobial drugs for resistant micro-organisms. Results: 2,4-Dihydroxybenzoic and protocatechuic acids were the phenolic compounds with higher activity against the majority of Gram-negative and Gram-positive bacteria. Furthermore, phenolic compounds inhibited more MRSA than methicillin-susceptible Staphylococcus aureus. MRSA was inhibited by 2,4-dihydroxybenzoic, vanillic, syringic (MICs = 0 5 mg ml 1) and p-coumaric (MIC = 1 mg ml 1) acids, while these compounds at the same concentrations had no inhibitory effects against methicillin-susceptible Staph. aureus. Conclusions: The presence of carboxylic acid (COOH), two hydroxyl (OH) groups in para and ortho positions of the benzene ring and also a methoxyl (OCH3) group in the meta position seems to be important for anti-MRSA activity. Significance and Impact of the Study: Phenolic compounds could be used as antimicrobial agents, namely against some micro-organisms resistant to commercial antibiotics.
Peer review: yes
URI: http://hdl.handle.net/10400.14/14313
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1111/jam.12196/abstract
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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