Utilize este identificador para referenciar este registo:
|Título:||Degradation of Fluoroquinolone Antibiotics and Identification of Metabolites/Transformation Products by LC-MS/MS|
|Autor:||Maia, Alexandra S.|
Ribeiro, Ana R.
Amorim, Catarina L.
Barreiro, Juliana C.
Cass, Quezia B.
Castro, Paula M.L.
Tiritan, Maria E.
|Citação:||MAIA, Alexandra S. [et al.] - Enantioselective Determination of Fluoxetine and Norfluoxetine in Wastewater. In 39th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Amsterdam, The Netherlands, 16-20 June 2013 – In HPLC 2013 - 39th International Symposium on High Performance Liquid Phase Separations and Related Techniques: Book of Abstracts, (2013) p.379|
|Resumo:||Antibiotics are a therapeutic class widely found inenvironmental matrices and extensively studied due to its persistence and implications for multi-resistant bacteria development. Degradation of four fluoroquinolone antibiotics, namely Ofloxacin (OFL), Norfloxacin (NOR), Ciprofloxacin (CPF) and Moxifloxacin (MOX), at 10 mg L-1 using a mixed bacterial culture, was assessed for 60 days. The assays were followed by a developed and validated analytical method of HPLC with Fluorescence Detection using a Luna PFP (2) 3µm column. The optimized conditions allowed picturing metabolites/transformation products formation and accumulation during the process, stating an incomplete mineralization, also shown byfluoride release. OFL and MOX presented the highest (98.3%) and the lowest (80.5%) extent of degradation after 19 days of assay, respectively. Some of these intermediate compounds were identified by LCMS/MS in selected degradation samples. Most of the intermediates were already described as biodegradation and/or photodegradationproducts in different conditions, but new and/or unknown metabolites were also present.|
|Aparece nas colecções:||CBQF - Resumos em actas / Abstracts in proceedings|
Ficheiros deste registo:
|HPLC 2013 AM ENVI14_TU.pdf||413,1 kB||Adobe PDF||Ver/Abrir|
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.